Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2
Open Access
- 6 January 2020
- journal article
- research article
- Published by MDPI AG in Pharmaceutics
- Vol. 12 (1), 49
- https://doi.org/10.3390/pharmaceutics12010049
Abstract
Diabetes mellitus (DM) has become a major health problem in most countries of the world. DM causes many complications, including hyperglycemia, diabetic ketoacidosis, and death. In Asia, mulberry has been used widely in the treatment of DM. Combination of drugs with herbal medicine may reduce the unwanted side effects caused by drugs. In this study, the influence of extended mulberry leaves extract (MLE) intake on metformin (Met) was evaluated in terms of pharmacokinetics and pharmacodynamics in DM-induced rats. Three week-treatment of MLE alone produced the anti-hyperglycemic effect (around 24%) if compared to the control. Interestingly, Met administration after MLE treatment for 3 weeks enhanced about 49% of the anti-hyperglycemic effect of Met. In addition, the extended intake of MLE potentiated the anti-hyperglycemic effect of Met on various concentrations. This potentiated anti-hyperglycemic effect of Met appears to be due to the pharmacokinetic change of Met. In this study, 3 week-treatment of MLE reduced the elimination of Met in DM-induced rats. In addition, MLE reduced the human organic cation transporter 2 (hOCT2) activity in a concentration-dependent manner. Thus, these findings suggest that MLE lowered the elimination of Met via inhibiting the hOCT2.Keywords
Funding Information
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (315024-3)
This publication has 46 references indexed in Scilit:
- Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced ExtractPLOS ONE, 2013
- Chlorogenic Acid and Rutin Play a Major Role in the In Vivo Anti-Diabetic Activity of Morus alba Leaf Extract on Type II Diabetic RatsPLOS ONE, 2012
- Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on DiabetesPLOS ONE, 2012
- Effect of natural products on commercial oral antidiabetic drugs in enhancing 2-deoxyglucose uptake by 3T3-L1 adipocytesTherapeutic Advances in Endocrinology and Metabolism, 2011
- Current views on type 2 diabetesJournal of Endocrinology, 2009
- Changes in metformin pharmacokinetics after intravenous and oral administration to rats with short‐term and long‐term diabetes induced by streptozotocinJournal of Pharmaceutical Sciences, 2008
- Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin actionJCI Insight, 2007
- The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects—A double blind placebo-controlled, crossover studyClinical Nutrition, 2006
- Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-α, PPAR-γ, and LPL mRNA expressionsLife Sciences, 2005
- Effects of dietary chemopreventive phytochemicals on P-glycoprotein functionBiochemical and Biophysical Research Communications, 2005