Background: Sexually transmitted diseases (STDs) affect men and women of all backgrounds and economic levels. CDC estimates that 19 million new infections occur each year, almost half of them among young people ages 15 to 24. Common STDs are acquired immune deficiency syndrome (AIDS), chancroid, genital HPV infection, gonorrhea, syphilis, trichomoniasis and viral hepatitis. The aim was to see the pattern of STDs in the skin and VD outpatient department (OPD), Sher-E-Bangla Medical College Hospital, Barishal, Bangladesh. Methods: The prospective observational study was conducted among 100 patients with STDs both male and female patients in the OPD of dermatology department of Sher-E-Bangla Medical College Hospital during the period from July 2015 to December 2015 irrespective of sex and age >15 years to assess the prevalence of sexually transmitted diseases. Results: In this study, prevalence of STDs such as gonorrhea, syphilis, non-gonococcal urethritis, chancroid, genital herpes and genital warts were observed. Gonorrhea was 28%, 13% were syphilis, non-gonococcal urethritis (NGU) was 43% and chancroid, genital herpes, genital warts were 5%, 7% and 4% respectively. Conclusions: STDs are becoming a major public health problem in our county. So, STDs have to be wiped in the bud by early diagnosis, efficient treatment and appropriate preventive and control measures.