The Biological Function of Extracellular Vesicles during Fertilization, Early Embryo—Maternal Crosstalk and Their Involvement in Reproduction: Review and Overview
Open Access
- 4 November 2020
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 10 (11), 1510
- https://doi.org/10.3390/biom10111510
Abstract
Secretory extracellular vesicles (EVs) are membrane-enclosed microparticles that mediate cell to cell communication in proximity to, or distant from, the cell of origin. Cells release a heterogeneous spectrum of EVs depending on their physiologic and metabolic state. Extracellular vesicles are generally classified as either exosomes or microvesicles depending on their size and biogenesis. Extracellular vesicles mediate temporal and spatial interaction during many events in sexual reproduction and supporting embryo-maternal dialogue. Although many omic technologies provide detailed understanding of the molecular cargo of EVs, the difficulty in obtaining populations of homogeneous EVs makes difficult to interpret the molecular profile of the molecules derived from a miscellaneous EV population. Notwithstanding, molecular characterization of EVs isolated in physiological and pathological conditions may increase our understanding of reproductive and obstetric diseases and assist the search for potential non-invasive biomarkers. Moreover, a more precise vision of the cocktail of biomolecules inside the EVs mediating communication between the embryo and mother could provide new insights to optimize the therapeutic action and safety of EV use.This publication has 182 references indexed in Scilit:
- Pregnancy recognition signaling mechanisms in ruminants and pigsJournal of Animal Science and Biotechnology, 2013
- Feed- and feed additives-related aspects of gut health and development in weanling pigsJournal of Animal Science and Biotechnology, 2013
- Evolution of diverse cell division and vesicle formation systems in ArchaeaNature Reviews Microbiology, 2010
- Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAsPLOS ONE, 2010
- Characterization of Yeast Extracellular Vesicles: Evidence for the Participation of Different Pathways of Cellular Traffic in Vesicle BiogenesisPLOS ONE, 2010
- ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane MicrovesiclesCurrent Biology, 2009
- Diverse functions of HBEGF during pregnancyMolecular Reproduction and Development, 2009
- The enterocyte microvillus is a vesicle-generating organelleThe Journal of cell biology, 2009
- Endocrine-Disrupting Chemicals: An Endocrine Society Scientific StatementEndocrine Reviews, 2009
- Circulating microRNAs as stable blood-based markers for cancer detectionProceedings of the National Academy of Sciences of the United States of America, 2008