Getting under the skin of Polycomb-dependent gene regulation
Open Access
- 1 March 2021
- journal article
- editorial
- Published by Cold Spring Harbor Laboratory in Journal of Bone and Joint Surgery
- Vol. 35 (5-6), 301-303
- https://doi.org/10.1101/gad.348257.121
Abstract
The Polycomb repressive system functions through chromatin to regulate gene expression and development. In this issue of Genes & Development, Cohen and colleagues (pp. 354–366) use the developing mouse epidermis as a model system to show that the two central Polycomb repressive complexes, PRC1 and PRC2, have autonomous yet overlapping functions in repressing Polycomb target genes. They show that this cooperation enables the stable repression of nonepidermal transcription factors that would otherwise compromise epidermal cell identity and disrupt normal skin development.Keywords
Funding Information
- Wellcome Trust (209400/Z/17/Z)
- European Research Council (681440)
This publication has 10 references indexed in Scilit:
- Polycomb complexes redundantly maintain epidermal stem cell identity during developmentGenes & Development, 2021
- The Complexity of PRC2 SubcomplexesTrends in Cell Biology, 2019
- Molecular Mechanisms Directing PRC2 Recruitment and H3K27 MethylationMolecular Cell, 2019
- Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNAMolecular Cell, 2019
- Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genesGenome Research, 2018
- Genome Regulation by Polycomb and Trithorax: 70 Years and CountingCell, 2017
- A High-Density Map for Navigating the Human Polycomb ComplexomeCell Reports, 2016
- Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin DevelopmentPLoS Genetics, 2016
- Targeting Polycomb systems to regulate gene expression: modifications to a complex storyNature Reviews Molecular Cell Biology, 2015
- Polycomb complexes act redundantly to repress genomic repeats and genesGenes & Development, 2010