Pathogenetic aspects of treatment of patients with genital endometriosis and syndrome of chronic pelvic pain in combination with "proliferative genital syndrome".
Open Access
- 25 June 2018
- journal article
- research article
- Published by Dnipro State Medical University in Medicni perspektivi
- Vol. 23 (2), 97-103
- https://doi.org/10.26641/2307-0404.2018.2.133945
Abstract
The aim of the work is to ascertain the efficiency of the use of an offered way of the complex treatment of the patients with genital endometriosis and combined benign pathologies of genitals and СРР. A differentiated approach to treatment and analysis of its effectiveness was conducted among the patients of the 1st and 2nd study groups (85 patients) with the severe and moderate pain syndrome according to the VAS scale. On the basis of analysis of immunohistochemical markers ER, PGR, Ki-67, VEGF, COX-2 inglands and in stroma the therapy was developed: Severe pain syndrome was eliminated in all patients within 3 months of treatment. A moderate level of pain was noted in 77.65%, after 12 months of observation in 16.47% of women, the remaining 83.53% noted a weak level of pain by VAS scale (p<0.05). The level of depression dropped (from 11,22±0,5 baseline to 5,98±0,24 ina year, p<0,001) by the Hamilton scale. This indicates the effectiveness of treatment.Keywords
This publication has 5 references indexed in Scilit:
- Strong Association Between Endometriosis and Symptomatic LeiomyomasJSLS : Journal of the Society of Laparoendoscopic Surgeons, 2016
- Neurotrophin Expression Is Not Affected in Uteri of Women with AdenomyosisJournal of Molecular Neuroscience, 2012
- Coexistence of adenomyosis in women operated for benign gynecological diseasesGynecological Endocrinology, 2011
- Do symptomatic endometriosis and uterine fibroids appear together?Journal of Human Reproductive Sciences, 2011
- COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic painEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2006