Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
Open Access
- 11 November 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (11), 3646
- https://doi.org/10.3390/jcm9113646
Abstract
The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence p < 0.001). Risk of metastatic or multisite recurrence was significantly higher in case of recurrence 18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrence.This publication has 27 references indexed in Scilit:
- Improved Survival with Bevacizumab in Advanced Cervical CancerThe New England Journal of Medicine, 2014
- Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancerCritical Reviews in Oncology/Hematology, 2014
- Platinum-free Interval in Second-line Chemotherapy for Recurrent Cervical CancerInternational Journal of Gynecologic Cancer, 2013
- Chemotherapy for metastatic and recurrent cervical cancerEmergencias, 2012
- A multi-institutional phase II trial of paclitaxel and carboplatin in the treatment of advanced or recurrent cervical cancerGynecologic Oncology, 2012
- Second platinum therapy in patients with uterine cervical cancer previously treated with platinum chemotherapyCancer Chemotherapy and Pharmacology, 2010
- Phase III Trial of Four Cisplatin-Containing Doublet Combinations in Stage IVB, Recurrent, or Persistent Cervical Carcinoma: A Gynecologic Oncology Group StudyJournal of Clinical Oncology, 2009
- Multimodality Therapy for Locally Advanced Cervical Carcinoma: State of the Art and Future DirectionsJournal of Clinical Oncology, 2007
- Carcinoma of the Cervix UteriInternational Journal of Gynecology & Obstetrics, 2006
- Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compoundsGynecologic Oncology, 1990