Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis
- 14 June 2021
- journal article
- research article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 27 (5), 639-644
- https://doi.org/10.1017/s1092852921000596
Abstract
Background Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD. Methods Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed using FreeSurfer. Results Compared to controls, BD patients had significantly lower volumes in the cingulate, medial-orbitofrontal (MOF) and parahippocampal regions. We found a negative correlation between right MOF volume and interferon-gamma levels (beta = -0.431, P = .049) and a positive correlation between interleukin-10 levels and left posterior cingulate volume (beta = 0.457, P = .048). Conclusion Our results support the involvement of inflammatory pathways in structural brain changes in BD.Keywords
This publication has 53 references indexed in Scilit:
- Grey matter differences in bipolar disorder: a meta‐analysis of voxel‐based morphometry studiesBipolar Disorders, 2012
- Voxelwise meta-analysis of gray matter reduction in major depressive disorderProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2012
- Echoes of the Brain within the Posterior Cingulate CortexJournal of Neuroscience, 2012
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based studyThe Lancet, 2009
- Assessing the role of cingulate cortex in bipolar disorder: Neuropathological, structural and functional imaging dataBrain Research Reviews, 2008
- Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorderInternational Journal of Neuropsychopharmacology, 2008
- The Brain's Default NetworkAnnals of the New York Academy of Sciences, 2008
- Reliability in multi-site structural MRI studies: Effects of gradient non-linearity correction on phantom and human dataNeuroImage, 2006
- Whole Brain Segmentation: Automated Labeling of Neuroanatomical Structures in the Human BrainNeuron, 2002
- Cortical Surface-Based Analysis: I. Segmentation and Surface ReconstructionNeuroImage, 1999