Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride
- 7 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Acta Pharmacologica Sinica
- Vol. 41 (12), 1568-1575
- https://doi.org/10.1038/s41401-020-0368-8
Abstract
Dyslipidemia is a risk factor for cardiovascular diseases and type 2 diabetes. Several adipokines play important roles in modulation of blood lipids. Metrnl is a recently identified adipokine, and adipose Metrnl participates in regulation of blood triglyceride (TG). In this study, we generated Metrnl global, intestine-specific and liver-specific knockout mice, and explored the effects of Metrnl on serum lipid parameters. Global knockout of Metrnl had no effects on serum lipid parameters under normal chow diet, but increased blood TG by 14%, and decreased total cholesterol (TC) by 16% and high density lipoprotein cholesterol (HDL-C) by 24% under high fat diet. Nevertheless, intestine-specific knockout of Metrnl did not alter the serum lipids parameters under normal chow diet or high fat diet. Notably, liver-specific knockout of Metrnl decreased HDL-C by 24%, TC by 20% and low density lipoprotein cholesterol (LDL-C) by 16% without alterations of blood TG and nonesterified fatty acids (NEFA) under high fat diet. But deficiency of Metrnl in liver did not change VLDL secretion and expression of lipid synthetic and metabolic genes. We conclude that tissue-specific Metrnl controls different components of blood lipids. In addition to modulation of blood TG by adipose Metrnl, blood HDL-C is regulated by liver Metrnl.Keywords
This publication has 23 references indexed in Scilit:
- Association of circulating adipokines with metabolic dyslipidemia in obese versus non-obese individualsDiabetes & Metabolic Syndrome: Clinical Research & Reviews, 2016
- Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ SignalingDiabetes, 2015
- Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPTScientific Reports, 2015
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat ThermogenesisCell, 2014
- Intestinal lipid absorption and lipoprotein formationCurrent Opinion in Lipidology, 2014
- Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain ExpressionCNS Neuroscience & Therapeutics, 2014
- Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivoExperimental Neurology, 2012
- A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderlyJournal of Lipid Research, 2004
- Diabetic Dyslipidemia: Causes and ConsequencesJournal of Clinical Endocrinology & Metabolism, 2001
- How LDL Receptors Influence Cholesterol and AtherosclerosisScientific American, 1984