The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer
Open Access
- 29 March 2022
- journal article
- Published by EpiSmart Science Vector Ltd in Asian Pacific Journal of Cancer Prevention
- Vol. 23 (3), 995-1003
- https://doi.org/10.31557/apjcp.2022.23.3.995
Abstract
Objective: The aim of this study was to improve the direct results of reconstructive surgery in patients operated on for complicated forms of colorectal cancer, by using 5-fluorouracil in the postoperative period. Methods: The study involved 126 patients (they were divided into 2 groups) with colorectal cancer, who underwent reconstructive surgery. They underwent a standard clinical examination and a mandatory examination program. Results: The use of 5-fluorouracil in adjuvant treatment in patients with colorectal cancer significantly reduces the number of subjective clinical manifestations (positional tests) in the main group – 17%, and in the control group – 54.3%, as well as objective clinical manifestations (instrumental research methods) in Group I – 13%, and Group II – 89.5%, respectively. The study shows that in re-operated patients with colorectal cancer who received 5-fluorouracil, abdominal adhesions are characterized by a low content of collagen and fibroblasts, low vascularization and a high content of polymerized fibrin strands. It was also found that re-operated patients with colorectal cancer who did not receive 5-fluorouracil, abdominal adhesions are characterized by a high collagen content, a large number of fibroblasts, and severe angiogenesis. Conclusion: It was found that the prolonged administration of 5-fluorouracil statistically significantly reduces the risk of adhesions, thereby showing the effectiveness of preventing adhesive disease of the abdominal organs. It was shown that the prolonged administration of 5-fluorouracil significantly reduces the number of subjective and objective signs of adhesive disease of the abdominal organs, as well as significantly decreases intraoperative and postoperative complications, the duration of the operation, and the amount of blood loss. In the postoperative period, it reduces the length of hospital stay and improves the quality of life of patients.Keywords
This publication has 11 references indexed in Scilit:
- Effects of carbon dioxide pneumoperitoneum on postoperative adhesion formation and oxidative stress in a rat cecal abrasion modelInternational Journal of Surgery, 2015
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012International Journal of Cancer, 2014
- Neoadjuvant Short- or Long-Term Radio(chemo)therapy for Rectal Cancer: How and Who Should Be Treated?Digestive Diseases, 2012
- The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in RatsInternational Journal of Molecular Sciences, 2012
- Young-age onset of colorectal cancer in IsraelTechniques in Coloproctology, 2009
- Feasibility and morbidity of reversal of Hartmann'sColorectal Disease, 2005
- The impact of conventional and laparoscopic colon resection (CO2 or helium) on intraperitoneal adhesion formation in a rat peritonitis modelSurgical Endoscopy, 2001
- Depression of peritoneal fibrinolysis during operation is a local response to traumaSurgery, 1998
- Quality of life in colorectal cancerDiseases of the Colon & Rectum, 1995
- Effective Surgical Adjuvant Therapy for High-Risk Rectal CarcinomaThe New England Journal of Medicine, 1991