Translational prospects of untethered medical microrobots
Open Access
- 1 July 2019
- journal article
- review article
- Published by IOP Publishing in Progress in Biomedical Engineering
- Vol. 1 (1), 012002
- https://doi.org/10.1088/2516-1091/ab22d5
Abstract
Untethered mobile microrobots have the potential to transform medicine radically. Their small size and wireless mobility can enable access to and navigation in confined, small, hard-to-reach, and sensitive inner body sites, where they can provide new ways of minimally invasive interventions and targeted diagnosis and therapy down to the cellular length scales with high precision and repeatability. The exponential recent progress of the field at the preclinical level raises anticipations for their near-future clinical prospects. To pave the way for this transformation to happen, however, the formerly proposed microrobotic system designs need a comprehensive review by including essential aspects that a microrobot needs to function properly and safely in given in vivo conditions of a targeted medical problem. The present review provides a translational perspective on medical microrobotics research with an application-oriented, integrative design approach. The blueprint of a medical microrobot needs to take account of microrobot shape, material composition, manufacturing technique, permeation of biological barriers, deployment strategy, actuation and control methods, medical imaging modality, and the execution of the prescribed medical tasks altogether at the same time. The incorporation of functional information pertaining each such element to the physical design of the microrobot is highly dependent on the specific clinical application scenario. We discuss the complexity of the challenges ahead and the potential directions to overcome them. We also throw light on the potential regulatory aspects of medical microrobots toward their bench-to-bedside translation. Such a multifaceted undertaking entails multidisciplinary involvement of engineers, materials scientists, biologists and medical doctors, and bringing their focus on specific medical problems where microrobots could make a disruptive or radical impact.Keywords
Funding Information
- Max-Planck-Gesellschaft
This publication has 165 references indexed in Scilit:
- Catalytic Janus Motors on Microfluidic Chip: Deterministic Motion for Targeted Cargo DeliveryACS Nano, 2012
- Biomedical applications of biodegradable polymersJournal of Polymer Science Part B: Polymer Physics, 2011
- Newly Engineered Magnetic Erythrocytes for Sustained and Targeted Delivery of Anti-Cancer Therapeutic CompoundsPLOS ONE, 2011
- Switch-based biosensors: a new approach towards real-time, in vivo molecular detectionTrends in Biotechnology, 2011
- Application of Molecular Ultrasound for Imaging Integrin ExpressionTheranostics, 2011
- Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeabilityJournal of Angiogenesis Research, 2010
- Collagen-based cell migration models in vitro and in vivoSeminars in Cell & Developmental Biology, 2009
- MRI-based Medical Nanorobotic Platform for the Control of Magnetic Nanoparticles and Flagellated Bacteria for Target Interventions in Human CapillariesThe International Journal of Robotics Research, 2009
- Shape Induced Inhibition of Phagocytosis of Polymer ParticlesPharmaceutical Research, 2008
- Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombiProceedings of the National Academy of Sciences of the United States of America, 2006