Association between Dyslipidemia and Mercury Exposure in Adults
Open Access
- 18 January 2021
- journal article
- research article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 18 (2), 775
- https://doi.org/10.3390/ijerph18020775
Abstract
Background—Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods—Using data from the seventh Korean National Health and Nutrition Examination Survey (2016–2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results—The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions—In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.Keywords
Funding Information
- Gachon University (GCU-2020-02950001)
This publication has 39 references indexed in Scilit:
- Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010Endocrine, 2013
- Reference levels of blood mercury and association with metabolic syndrome in Korean adultsInternationales Archiv für Arbeitsmedizin, 2013
- Diet Quality of Americans Differs by Age, Sex, Race/Ethnicity, Income, and Education LevelJournal of the Academy of Nutrition and Dietetics, 2013
- Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix PolygalaJournal of Biomedicine and Biotechnology, 2012
- Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity miceToxicology and Applied Pharmacology, 2012
- Toxic Effects of Mercury on the Cardiovascular and Central Nervous SystemsJournal of Biomedicine and Biotechnology, 2012
- Relationship Between Blood Mercury Concentration and Waist-to-Hip Ratio in Elderly Korean Individuals Living in Coastal AreasJournal of Preventive Medicine & Public Health, 2011
- Heavy Metal Poisoning and Cardiovascular DiseaseJournal of Toxicology, 2011
- Dyslipidemia in type 2 diabetes mellitusNature Reviews Endocrinology, 2009
- Role of adipocytokines in obesity-associated insulin resistanceThe Journal of Nutritional Biochemistry, 2008