A circuit perspective on narcolepsy
Open Access
- 10 January 2020
- journal article
- review article
- Published by Oxford University Press (OUP) in Sleep
- Vol. 43 (5)
- https://doi.org/10.1093/sleep/zsz296
Abstract
The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.Keywords
Funding Information
- University of Bern
- Bern University Hospital
- Human Frontier Science Program (RGY0076/2012)
- Inselspital University Hospital Bern
- Swiss National Science Foundation (31003A_156156)
- European Research Council (725850)
- Sinergia (CRSII3_160803)
- National Institutes of Health (DK105510, R01 NS106032)
- National Science Foundation (1652060)
- Takeda Pharmaceuticals
- Merck
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