The domestication of animals was part of a major transformation in the way of life of an increasing number of human societies with deep social and spiritual changes. In the present study, we report about utility of Nilgai and the values of its products and how it can add variety in our diet. Domestication of Nilgai may prove as an outstanding diet (veal and juveniles) for human and domesticated carnivores it may be the most important achievements that man-made in his cultural history. It is very useful and has many kinds of beneficial mutualism with man exists. We also prerequisite to reconnoiter biological functions, importance, and distinctiveness of products viz milk, meat, leather and body parts such as skin, teeth, nail and other product in addition to transportation and export, because of their size and powerful appearance. The meat of Nilgai is said to be lighter and milder flavored than that of blackbuck meat. A domesticated animal such as livestock plays a vital role in diversified farming systems because food and recycling of nutrients through the farm are well proven. Nilgai appears to have different color which occurs during the developmental stage, like a fawn, juveniles and adults. Few Nilgai showed some docility behavior in nature subsequently that sighs of taming towards domestication. Nilgai may prove a higher status than other domestic animals when it comes to success in domestication. The Nilgai dwelling near the human habitation in proximity to a close distance in anthropogenic and share with its habitat and graze food and fodders with domestic herbivore mammals like goat, buffalos’ and cow in the periphery of the village’s areas. The domestication of Nilgai corresponds to a pivotal change in history not only of humanity but also of the biosphere.