Targeting defective sphingosine kinase 1 in Niemann?Pick type C disease with an activator mitigates cholesterol accumulation
Open Access
- 3 July 2020
- journal article
- research article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 295 (27), 9121-9133
- https://doi.org/10.1074/jbc.RA120.012659
Abstract
No abstract availableFunding Information
- HHS | NIH | National Institute of General Medical Sciences (R01GM043880)
- HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (K99HD096117)
This publication has 69 references indexed in Scilit:
- Autophagy modulation as a potential therapeutic target for diverse diseasesNature Reviews Drug Discovery, 2012
- Truth and consequences of sphingosine-1-phosphate lyaseAdvances in Biological Regulation, 2012
- Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in miceProceedings of the National Academy of Sciences of the United States of America, 2011
- The outs and the ins of sphingosine-1-phosphate in immunityNature Reviews Immunology, 2011
- Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in LysosomesCell Metabolism, 2010
- Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cellsProceedings of the National Academy of Sciences of the United States of America, 2010
- Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of CholesterolCell, 2009
- Autophagy regulates lipid metabolismNature, 2009
- NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomesProceedings of the National Academy of Sciences of the United States of America, 2008
- Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein MisfoldingPublished by Elsevier BV ,2008