The Role of Mitochondria in Pyroptosis
Open Access
- 21 January 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
Pyroptosis is a recently discovered aspartic aspart-specific cysteine protease (Caspase-1/4/5/11) dependent mode of gene-regulated cell death cell death, which is represented by the rupture of cell membrane perforations and the production of proinflammatory mediaters like interleukin-18(IL-18) and interleukin-1β (IL-1β). Mitochondria also play an important role in apoptotic cell death. When it comes to apoptosis of mitochondrion, mitochondrial outer membrane permeabilization (MOMP) is commonly known to cause cell death. As a downstream pathological process of apoptotic signaling, MOMP participates in the leakage of cytochrome-c from mitochondrion to the cytosol and subsequently activate caspase proteases. Hence, targeting MOMP for the sake of manipulating cell death presents potential therapeutic effects among various types of diseases, such as autoimmune disorders, neurodegenerative diseases, and cancer. In this review, we highlights the roles and significance of mitochondria in pyroptosis to provide unexplored strategies that target the mitochondria to regulate cell death for clinical benefits.Keywords
This publication has 69 references indexed in Scilit:
- BID-induced structural changes in BAK promote apoptosisNature Structural & Molecular Biology, 2013
- Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic PrimingMolecular Cell, 2013
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell DeathCell, 2012
- Bax dimerizes via a symmetric BH3:groove interface during apoptosisCell Death & Differentiation, 2011
- Bcl-xL Retrotranslocates Bax from the Mitochondria into the CytosolCell, 2011
- Mitochondria and cell death: outer membrane permeabilization and beyondNature Reviews Molecular Cell Biology, 2010
- The InflammasomesCell, 2010
- Molecular Details of Bax Activation, Oligomerization, and Membrane InsertionOnline Journal of Public Health Informatics, 2010
- Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial MembraneYonsei Medical Journal, 2008
- Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and DeathScience, 2001