Magnetic fields enhance the anti-tumor efficacy of low dose cisplatin and reduce the nephrotoxicity
- 21 March 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 393 (8), 1475-1485
- https://doi.org/10.1007/s00210-020-01855-9
Abstract
The present work was to examine a combination of therapy for a low dose of cisplatin and a magnetic field (MF) on Ehrlich carcinoma-bearing mice. In this study, a total of 50 BALB/C female mice were equally distributed into five groups. Mice from the control group did not receive MF or cisplatin. The low and high dose cisplatin groups were injected intraperitoneal (i.p.) with 3 and 6 mg/kg cisplatin, respectively, on the experimental days (1, 4, and 8). Mice group of cisplatin + MF was injected with a low dose of cisplatin followed by MF exposure (50 Hz, 50 mT), and the MF group was exposed to MF only. The impact of MF and cisplatin on the tumor and kidney were evaluated by measuring superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels, DNA injury (comet assay), histopathological investigation of tissues, and tumor progress. The results suggested that the combination of a low dose of cisplatin with MF was significantly elevated in MDA levels, reduced SOD activity, and GSH levels. Furthermore, it caused a rise in comet parameters and inhibition in tumor growth. These results showed that MF enhances the therapeutic efficacy of low cisplatin doses and reduces nephrotoxicity.Keywords
This publication has 56 references indexed in Scilit:
- Extremely Low-Frequency Magnetic Field Enhances the Therapeutic Efficacy of Low-Dose Cisplatin in the Treatment of Ehrlich CarcinomaBioMed Research International, 2013
- Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53Toxicology and Applied Pharmacology, 2012
- Assessment of the Evolution of Cancer Treatment TherapiesCancers, 2011
- Static Magnetic Fields Enhanced the Potency of Cisplatin on K562 CellsCancer Biotherapy & Radiopharmaceuticals, 2010
- Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper ChelatorCancer Cell, 2010
- Medical applications of electromagnetic fieldsIOP Conference Series: Earth and Environmental Science, 2010
- Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of ratsChemico-Biological Interactions, 2007
- Apoptosis: A Link between Cancer Genetics and ChemotherapyCell, 2002
- A simple technique for quantitation of low levels of DNA damage in individual cellsExperimental Cell Research, 1988
- Cisplatin (cis-diamminedichloroplatinum II)Cancer Treatment Reviews, 1979