Systemic Sclerosis and Vaccinations: A Register-Based Cohort Study about Seasonal Influenza and Streptococcus pneumoniae Vaccination Rate and Uptake from Liguria Regional Center, Northwest Italy
Open Access
- 27 April 2020
- Vol. 8 (2), 204
- https://doi.org/10.3390/vaccines8020204
Abstract
Systemic sclerosis (SSc) is the connective tissue disease with the highest mortality and patients with chronic inflammatory immune-mediated diseases are at high risk of acquiring infections as they are often treated with immunosuppressive or biological drugs. This study, conducted among the patients followed by our clinical immunology, part of the Internal Medicine Department in the Ospedale Policlinico San Martino, Genoa, northwest Italy, has set itself the primary objective of analyzing the vaccine uptake and the vaccination coverage against both seasonal influenza and S. pneumoniae in a cohort of patients with SSc. We evaluated the influenza and pneumococcal vaccination rate among various subgroups of patients and the source of the recommendation for vaccination. We evaluated the vaccination rate changes between the two years considered in our study. We also calculated a binomial logistic regression between vaccination acceptance and clinical and demographics characteristics of the patients to evaluate the adjusted odds ratio (OR) of each factor on vaccination. The vaccination coverage that resulted was significantly higher than in other similar studies. Age over 65 years old, interstitial lung disease, and ongoing immunosuppressive therapy were significantly related with acceptance to both vaccinations using univariate analyses, but the multivariate logistic regression found a significant correlation only with the age and therapy factors.This publication has 35 references indexed in Scilit:
- Rheumatoid arthritis and the incidence of influenza and influenza-related complications: a retrospective cohort studyBMC Musculoskeletal Disorders, 2012
- Pneumonia in allogeneic stem cell transplantation recipients: a multicenter prospective studyClinical Transplantation, 2011
- Vaccination in adult patients with auto-immune inflammatory rheumatic diseases: A systematic literature review for the European League Against Rheumatism evidence-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseasesAutoimmunity Reviews, 2011
- Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta‐AnalysisClinical Infectious Diseases, 2010
- Geoepidemiology of systemic sclerosisAutoimmunity Reviews, 2010
- Low influenza vaccination rate among patients with systemic sclerosisRheumatology, 2009
- Vaccinate your child and save its grandparents from a heart attack? Current perspectives in antipneumococcal vaccinationJournal of Internal Medicine, 2009
- Vaccines: Vaccination in Patients with Chronic Rheumatic or Autoimmune DiseasesClinical Infectious Diseases, 2008
- Renal complications and scleroderma renal crisisRheumatology, 2006
- Non-Antigen-Specific CD8+ T Suppressor Lymphocytes in Diseases Characterized by Chronic Immune Responses and InflammationAnnals of the New York Academy of Sciences, 2005