Cyanation of glycine derivatives
- 13 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 57 (24), 3014-3017
- https://doi.org/10.1039/d0cc08126d
Abstract
We report a catalytic oxidative C–H cyanation of glycine derivatives using a simple copper(I) catalyst with NFSI as an oxidant via a radical process to furnish α-cyano glycine derivatives, which are useful intermediates for organic synthesis. CuCl acted as both a one-electron reductant and a transition-metal catalyst in this transformation. NFSI served as a one-electron oxidant and generated a N-centered radical as a H-abstractor. The reaction displayed broad substrate scope and mild reaction conditions.Keywords
Funding Information
- National Natural Science Foundation of China (21961033)
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