microRNA dynamic expression regulates invariant NKT cells
- 8 July 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 78 (16), 6003-6015
- https://doi.org/10.1007/s00018-021-03895-7
Abstract
Invariant natural killer T cells (iNKT) are a prevalent population of innate-like T cells in mice, but quite rare in humans that are critical for regulation of the innate and adaptive immune responses during antimicrobial immunity, tumor rejection, and inflammatory diseases. Multiple transcription factors and signaling molecules that contribute to iNKT cell selection and functional differentiation have been identified. However, the full molecular network responsible for regulating and maintaining iNKT populations remains unclear. MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that regulate gene expression post-transcriptionally. Previous reports uncovered the important roles of miRNAs in iNKT cell development and function using Dicer mutant mice. In this review, we discuss the emerging roles of individual miRNAs in iNKT cells reported by our group and other groups, including miR-150, miR-155, miR-181, let-7, miR-17 ~ 92 cluster, and miR-183-96-182 cluster. It is likely that iNKT cell development, differentiation, homeostasis, and functions are orchestrated through a multilayered network comprising interactions among master transcription factors, signaling molecules, and dynamically expressed miRNAs. We provide a comprehensive view of the molecular mechanisms underlying iNKT cell differentiation and function controlled by dynamically expressed miRNAs.Keywords
Funding Information
- Foundation for the National Institutes of Health (1R01AI119041)
- Henry Ford Health System (T71016, T71017)
This publication has 120 references indexed in Scilit:
- MicroRNA control of lymphocyte differentiation and functionCurrent Opinion in Immunology, 2011
- Development of PLZF-expressing innate T cellsCurrent Opinion in Immunology, 2011
- A non‐redundant role for OX40 in the competitive fitness of Treg in response to IL‐2European Journal of Immunology, 2010
- Regulation of MicroRNA Expression and Abundance during LymphopoiesisImmunity, 2010
- Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cellsJournal of Hepatology, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 ProteinImmunity, 2009
- The Transcription Factor PLZF Directs the Effector Program of the NKT Cell LineageImmunity, 2008
- MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte ProgenitorsDevelopmental Cell, 2008
- MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine DeaminaseImmunity, 2008