Machine learning volumetry of ischemic brain lesions on CT after thrombectomy—prospective diagnostic accuracy study in ischemic stroke patients
- 22 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neuroradiology
- Vol. 62 (10), 1239-1245
- https://doi.org/10.1007/s00234-020-02419-7
Abstract
Purpose Ischemic lesion volume (ILV) is an important radiological predictor of functional outcome in patients with anterior circulation stroke. Our aim was to assess the agreement between automated ILV measurements on NCCT using the Brainomix software and manual ILV measurements on diffusion-weighted imaging (DWI). Methods This was a prospective single-center observational study of patients with CT angiography (CTA) proven anterior circulation occlusion treated with endovascular thrombectomy (May 2018 to May 2019). NCCT ILV was measured automatically by the Brainomix software. DWI ILV was measured manually. The McNemar’s test was used to test sensitivity and specificity. The Somer’s delta was used to test the differences between concordant and discordant ASPECTS regions. The Bland-Altman plot was calculated to compare the differences between Brainomix and DWI ILVs. Results Forty-five patients were included. Median Brainomix ILV was 23 ml (interquartile range [IQR], 15–39 ml), and median DWI ILV was 11.5 ml (IQR, 7–32 ml) in the TICI 2b-3 group. In the TICI 0-2a, the NCCT ILV was 39 ml (IQR, 18–62 ml) and DWI ILV was 30 (IQR, 11–105 ml). The DWI ILVs in patients with good clinical outcome (mRS 0–2) was significantly lower compared with patients with mRS ≥ 3 (10 mL vs 59 mL, p = 0.002). Similar trend was observed for Brainomix ILV measurements (21 mL vs 39 mL, p = 0.012). There was a high correlation and accuracy in the detection of follow-up ischemic changes in particular ASPECTS regions. Conclusion NCCT ILV measured automatically by the Brainomix software might be considered a valuable radiological outcome measure.Funding Information
- Ministerstvo Zdravotnictví Ceské Republiky (FNOs/2018)
This publication has 10 references indexed in Scilit:
- Reperfusion and Clinical Outcomes in Acute Ischemic Stroke: Systematic Review and Meta-Analysis of the Stent-Retriever-Based, Early Window Endovascular Stroke TrialsFrontiers in Neurology, 2018
- e-ASPECTS Correlates with and Is Predictive of Outcome after Mechanical ThrombectomyAmerican Journal of Neuroradiology, 2017
- Associations of Ischemic Lesion Volume With Functional Outcome in Patients With Acute Ischemic StrokeStroke, 2017
- e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patientsInternational Journal of Stroke, 2016
- Performance of e-ASPECTS software in comparison to that of stroke physicians on assessing CT scans of acute ischemic stroke patientsInternational Journal of Stroke, 2016
- Relationships Between Imaging Assessments and Outcomes in Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic StrokeStroke, 2015
- Pittsburgh Outcomes After Stroke Thrombectomy Score Predicts Outcomes After Endovascular Therapy for Anterior Circulation Large Vessel OcclusionsStroke, 2014
- Final Infarct Volume Is a Stronger Predictor of Outcome Than Recanalization in Patients With Proximal Middle Cerebral Artery Occlusion Treated With Endovascular TherapyStroke, 2012
- Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke TherapyStroke, 2012
- Diffusion-Weighted Magnetic Resonance Imaging in Acute StrokeStroke, 1998