Clinicopathological features of breast cancer patients with internal mammary and/or supraclavicular lymph node recurrence without distant metastasis
Open Access
- 29 September 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 20 (1), 1-9
- https://doi.org/10.1186/s12885-020-07442-8
Abstract
BackgroundInternal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes.MethodsWe enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007 and December 2012. Clinicopathological features of patients with IM-SC LN recurrence and patients with DM were retrospectively reviewed.ResultsWith a median follow-up time 78 (range, 13-125) months after the primary operation, 14 (0.3%) had IM-SC LN recurrence without DM and 274 (6.5%) had DM at the first recurrence among 4237 patients. No statistical differences were found in the baseline characteristics of the primary tumor between the two groups. The 5-year overall survival (OS) rate after recurrence in patients with IM-SC LN recurrence was 51% compared with 27% in patients with DM (P=0.040). In patients with IM-SC LN recurrence, clinically positive axillary LN at diagnosis and pathologically positive axillary LN at primary surgery were poor prognostic factors for distant disease-free survival (DDFS) (P=0.004 and 0.007, respectively). Clinical and pathological axillary nodal status at primary surgery was associated with OS (P=0.011 and 0.001, respectively).ConclusionsPatients with IM-SC LN recurrence without DM who had no clinical and pathological axillary LNs involved at primary surgery had a favorable prognosis. A larger validation study is required.This publication has 20 references indexed in Scilit:
- Prognosis After Ipsilateral Breast Tumor Recurrence and Locoregional Recurrences in Patients Treated by Breast-Conserving Therapy in Five National Surgical Adjuvant Breast and Bowel Project Protocols of Node-Negative Breast CancerJournal of Clinical Oncology, 2009
- Regional Nodal Recurrence After Breast Conservation Treatment With Radiotherapy for Women With Early-Stage Breast CarcinomaInternational Journal of Radiation Oncology*Biology*Physics, 2009
- Prognosis of Breast Cancer After Supraclavicular Lymph Node Metastasis: Not a Distant MetastasisAnnals of Surgical Oncology, 2006
- Management and Outcomes of Isolated Axillary Node Recurrence in Breast CancerArchives of Surgery, 2006
- Prognosis After Ipsilateral Breast Tumor Recurrence and Locoregional Recurrences in Five National Surgical Adjuvant Breast and Bowel Project Node-Positive Adjuvant Breast Cancer TrialsJournal of Clinical Oncology, 2006
- Breast Cancer Staging: Working With the Sixth Edition of the AJCC Cancer Staging ManualCA: A Cancer Journal for Clinicians, 2006
- Prognosis after regional lymph node recurrence in patients with Stage I–II breast carcinoma treated with breast conservation therapyCancer, 2003
- Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast CancerThe New England Journal of Medicine, 2002
- Local-Regional Breast Cancer Recurrence: Prognostic Groups Based on Patterns of FailureThe Breast Journal, 2002
- Presentation, management and outcome of axillary recurrence from breast cancerThe American Journal of Surgery, 2000