Potential applications of low-intensity extracorporeal shock-wave therapy in urological diseases via activation of tissue resident stem cells
- 1 January 2022
- journal article
- review article
- Published by Medknow in Urological Science
- Vol. 33 (1), 3-8
- https://doi.org/10.4103/uros.uros_56_21
Abstract
For many years, low-intensity extracorporeal shock-wave therapy (Li-ESWT) has been clinically applied as a noninvasive therapeutic method, for urological diseases. The major corresponding biological molecular mechanisms of Li-ESWT are to induce stem cell differentiation, neural regeneration, and angiogenesis. This narrative review aims to present an overview of the potential utility of Li-ESWT and its effects on stem cell therapies. Recent studies have also shown that the combination treatment of Li-ESWT and stem cell therapies can be a new option for the treatment of erectile dysfunction (ED), urinary incontinence, bladder dysfunction, and other diseases. The potential contributions of Li-ESWT on stem cell therapies for these diseases are studied, highlighting the influence of Li-ESWT on proliferation, viability, and differentiation capacity of certain stem cells. The potential mechanisms, including the increased expression of vascular endothelial growth factor, chemokine CXC motif ligand 5, and transforming growth factor-β1 are described herein. Li-ESWT can also activate many cellular signaling pathways. The combination of Li-ESWT and stem cell therapies is a promising strategy for urological diseases. However, a much greater understanding of the mechanisms by which Li-ESWT enhances the efficacy of stem cell therapy is still needed before this combined treatment can be recommended for large-scale clinical application.Keywords
This publication has 52 references indexed in Scilit:
- Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: Implications for angiogenesis and vasculogenesisThe Journal of Thoracic and Cardiovascular Surgery, 2013
- Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic RatsInternational Journal of Molecular Sciences, 2013
- Adipose Tissue-Derived Stem Cells Ameliorate Diabetic Bladder Dysfunction in a Type II Diabetic Rat ModelStem Cells and Development, 2012
- Low-Intensity Extracorporeal Shock Wave Therapy—A Novel Effective Treatment for Erectile Dysfunction in Severe ED Patients Who Respond Poorly to PDE5 Inhibitor TherapyThe Journal of Sexual Medicine, 2012
- Effects of transplantation of adipose tissue‐derived stem cells on prostate tumorThe Prostate, 2010
- Extracorporeal shock‐wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ‐induced diabetesWound Repair and Regeneration, 2009
- Extracorporeal Shock Wave-Mediated Changes in Proliferation, Differentiation, and Gene Expression of Human OsteoblastsThe Journal of Trauma and Acute Care Surgery, 2008
- Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor CellsCirculation, 2006
- Wnt signalling regulates adult hippocampal neurogenesisNature, 2005
- Recruitment of mesenchymal stem cells and expression of TGF‐β1 and VEGF in the early stage of shock wave‐promoted bone regeneration of segmental defect in ratsJournal of Orthopaedic Research, 2004