δ Subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice
Open Access
- 17 July 2017
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 24 (8), 381-384
- https://doi.org/10.1101/lm.045856.117
Abstract
The role of δ subunit-containing GABAA receptor (GABAA(δ)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion of GABAA(δ)R and using protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, we observed that when the two tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more than their wild-type littermates to the nonconditioned but not conditioned stimuli. Thus, GABAA(δ)R may prevent inappropriate fear generalization when the incoming stimuli differ clearly from the learned threat.Keywords
Funding Information
- National Natural Science Foundation of China (31160208, 91332123, 81601179)
- National Basic Research Program of China (2014CB846100)
- Program for New Century Excellent Talents in Universities of China
- “555 project,”
- Scientific Project of Jiangxi Province (20143ACB21002, KJLD14013)
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