Personalized Healthcare for Dementia
Open Access
- 28 January 2021
- journal article
- review article
- Published by MDPI AG in Healthcare
- Vol. 9 (2), 128
- https://doi.org/10.3390/healthcare9020128
Abstract
Dementia is one of the most common health problems affecting older adults, and the population with dementia is growing. Dementia refers to a comprehensive syndrome rather than a specific disease and is characterized by the loss of cognitive abilities. Many factors are related to dementia, such as aging, genetic profile, systemic vascular disease, unhealthy diet, and physical inactivity. As the causes and types of dementia are diverse, personalized healthcare is required. In this review, we first summarize various diagnostic approaches associated with dementia. Particularly, clinical diagnosis methods, biomarkers, neuroimaging, and digital biomarkers based on advances in data science and wearable devices are comprehensively reviewed. We then discuss three effective approaches to treating dementia, including engineering design, exercise, and diet. In the engineering design section, recent advances in monitoring and drug delivery systems for dementia are introduced. Additionally, we describe the effects of exercise on the treatment of dementia, especially focusing on the effects of aerobic and resistance training on cognitive function, and the effects of diets such as the Mediterranean diet and ketogenic diet on dementia.Funding Information
- The Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2016R1A2B4014240, NRF-2018R1A2A3074577, NRF- 2019S1A5C2A03082727)
This publication has 124 references indexed in Scilit:
- Plasma Processing Conditions Substantially Influence Circulating microRNA Biomarker LevelsPLOS ONE, 2013
- Dietary ketosis enhances memory in mild cognitive impairmentNeurobiology of Aging, 2012
- Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2Brain, 2010
- The clinical use of structural MRI in Alzheimer diseaseNature Reviews Neurology, 2010
- Effects of Aerobic Exercise on Mild Cognitive ImpairmentArchives of Neurology, 2010
- Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of DementiaJAMA, 2009
- Mediterranean Diet and Mild Cognitive ImpairmentArchives of Neurology, 2009
- Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRSNMR in Biomedicine, 2006
- Mediterranean diet and risk for Alzheimer's diseaseAnnals of Neurology, 2006
- Biomarkers and surrogate endpoints: Preferred definitions and conceptual frameworkClinical Pharmacology & Therapeutics, 2001