| A cross-sectional study using random sampling was conducted from May to September 2020 in Benadir region of Somalia, to determine the knowledge, attitude, and practices of population towards Brucellosis. In this study, a total of 120 participants share their knowledge, attitude, and practices towards Brucellosis. Their knowledge regarding causative agent was 37.5% (n=45) and the disease was 45% (n=54), while transmission of animal to human was 43.33% (n=52). The majority of participants would take actions to ensure the animal is healthy when they buy 95% (n=114), all participants would like to receive more information about the disease and majority of participants have good practices when they handling the domesticated animals and their secretions 96.66% (n=116). Populations who are connected with livestock management or eating livestock products are frequently aware of the disease brucellosis. Though, they do not have as considerable knowledge, what is required to help in control it. Veterinarians, health care workers and respective government bodies must take action to increase the level of awareness and considerate by providing programs or any other technique that can be helpful.