Autonomous Sensory Meridian Response (ASMR) describes a tingly physical response triggered by specific visual and auditory stimuli such as whispering, personal attention, crisp sounds and slow movements. Some investigations find that ASMR is associated with specific personality traits such as openness. There also exist individual differences in functional neural connectivity across individuals who do and do not experience ASMR. The similarity and high correlation between ASMR and frisson and misophonia allow us to guess the possible formation mechanism of ASMR from the perspective of those two. The high correlation with mindfulness reveals the potential for assisting psychotherapy.