Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-a][1,3,5]triazines
Open Access
- 10 June 2021
- Vol. 26 (12), 3540
- https://doi.org/10.3390/molecules26123540
Abstract
This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups. This study confirms the interest of combining the efficient heating obtained under dielectric microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol is featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis.This publication has 36 references indexed in Scilit:
- Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-onesBioorganic Chemistry, 2013
- Heterocyclic Synthesis with 4-Benzoyl-1-cyanoacetylthiosemicarbazide: Selective Synthesis of Some Thiazole, Triazole, Thiadiazine, Pyrrylthiazole, and Pyrazolo[1,5-a]triazine DerivativesMonatshefte für Chemie / Chemical Monthly, 2008
- Pyrazolo[1,5-a][1,3,5]triazines (5-Aza-9-deazapurines): Synthesis and Biological ActivityHETEROCYCLES, 2008
- Synthesis of 8‐Substituted Pyrazolo[1,5‐a]‐1,3,5‐triazine Derivatives by Palladium‐Catalyzed Cross‐Coupling Reactions.ChemInform, 2007
- Synthesis of 8-Substituted Pyrazolo[1,5-a]-1,3,5-triazine Derivatives by Palladium-Catalyzed Cross-Coupling ReactionsSynthesis, 2006
- 1,2,4‐Triazolo[1,5‐a][1,3,5]triazines (5‐Azapurines): Synthesis and Biological ActivityChemInform, 2006
- A facile synthesis of 8‐(β‐D‐ribofuranosyl)‐4‐thioxo‐3H‐pyrazolo[1,5‐a]‐1,3,5‐triazine and its α‐anomerJournal of Heterocyclic Chemistry, 1984
- Nucleosides.117. Synthesis of 4-oxo-8-(β-D-ribofuranosyl)-3H-pyrazolo[1,5-a]-1,3,5-triazine (OPTR)via3-amino-2N-carbamoyl-4-(β-D-ribofuranosyl)pyrazole (ACPR) derivativesJournal of Heterocyclic Chemistry, 1980
- Synthesis of 1,3-dialkylpyrazolo [1,5-a]-1,3,5-triazine-2,4-diones isomers of 1,3-dialkylxanthinesJournal of Heterocyclic Chemistry, 1975
- The chemistry of 4‐hydrazino‐7‐phenylpyrazolo[1,5‐a] ‐1,3,5‐triazinesJournal of Heterocyclic Chemistry, 1974