Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia
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Open Access
- 1 April 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 10 (4), 536-551
- https://doi.org/10.1158/2159-8290.cd-19-0710
Abstract
Compared with less differentiated acute myeloid leukemia (AML), monocytic AML is more resistant to venetoclax-based therapy, a phenomenon that may be attributable to dedifferentiation of preexisting monocytic subclones.Keywords
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Funding Information
- NIH (R01CA200707)
- University of Colorado
- Department of Medicine Outstanding Early Career Scholar Program
- Leukaemia and Lymphoma Research
- Leukaemia and Lymphoma Research
- E.P. Evans Foundation Biff Ruttenberg Foundation
- NIH (GM008497, 25A5072)
- Boettcher Foundation
- Leukemia and Lymphoma Society
- American Cancer Society (25A5072)
- University of Colorado Cancer Center (P30CA046934)
This publication has 49 references indexed in Scilit:
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid LeukemiaThe New England Journal of Medicine, 2013
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsNature Medicine, 2013
- Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitorsJCI Insight, 2012
- Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid LeukemiaCancer Cell, 2011
- Metabolic state of glioma stem cells and nontumorigenic cellsProceedings of the National Academy of Sciences of the United States of America, 2011
- Densely Interconnected Transcriptional Circuits Control Cell States in Human HematopoiesisCell, 2011
- Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem CellsCell Stem Cell, 2009
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9Nature, 2006
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- CD14: Cell surface receptor and differentiation markerImmunology Today, 1993