Multi-Modal Imaging in Down's Syndrome: Maximizing Utility Through Innovative Neuroimaging Approaches
Open Access
- 7 January 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Neurology
Abstract
In recent decades, the field of neuroimaging has experienced a surge of popularity and innovation which has led to significant advancements in the understanding of neurological disease, if not immediate clinical translation. In the case of Down's syndrome, a complex interplay of neurodevelopmental and neurodegenerative processes occur as a result of the trisomy of chromosome 21. The substantial potential impact of improved clinical intervention and the limited research under-taken to date make it a prime candidate for longitudinal neuroimaging-based study. However, as with a multitude of other multifaceted brain-based disorders, singular utilization of lone modality imaging has limited interpretability and applicability. Indeed, a present challenge facing the neuroimaging community as a whole is the methodological integration of multi-modal imaging to enhance clinical understanding. This review therefore aims to assess the current literature in Down's syndrome utilizing a multi-modal approach with regards to improvement upon consideration of a single modality. Additionally, we discuss potential avenues of future research that may effectively combine structural, functional and molecular-based imaging techniques for the significant benefit of the understanding of Down's syndrome pathology.This publication has 41 references indexed in Scilit:
- New anatomic MRI techniquesEpilepsia, 2010
- Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's diseaseBrain, 2009
- Classification of brain tumor type and grade using MRI texture and shape in a machine learning schemeMagnetic Resonance in Medicine, 2009
- The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive IndividualsCerebral Cortex, 2008
- Neuroimaging of individuals with Down’s syndrome at-risk for dementia: Evidence for possible compensatory eventsNeuroImage, 2008
- Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated PedigreesJournal of Neuroscience, 2007
- Alzheimer's disease in Down syndrome: Neurobiology and riskMental Retardation and Developmental Disabilities Research Reviews, 2007
- Chromosome 21 and Down syndrome: from genomics to pathophysiologyNature Reviews Genetics, 2004
- Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's diseaseAnnals of Neurology, 1997
- ALZHEIMER'S PRESENILE DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWN'S SYNDROME IN MIDDLE AGE FORM AN AGE RELATED CONTINUUM OF PATHOLOGICAL CHANGESNeuropathology and Applied Neurobiology, 1984