Variations of body mass and thermogenesis properties in Eothenomys olitor during cold acclimatization
- 18 November 2021
- journal article
- research article
- Published by Brill in Animal Biology
- Vol. 71 (4), 407-421
- https://doi.org/10.1163/15707563-bja10062
Abstract
The set-point hypothesis states that there is a biological control method in mammals that actively regulates weight toward a predetermined set weight for each individual, which may occur by regulation of energy intake or energy expenditure. In order to investigate the effects of low temperature on body mass regulation in Eothenomys olitor, body mass, body fat mass, food intake, resting metabolic rate (RMR), non-shivering thermogenesis (NST), serum leptin levels, morphology, biochemical indexes of liver and brown adipose tissue (BAT) and hypothalamic neuropeptide genes expression were measured during cold acclimatization. The results showed that there was no significant difference in body mass, but food intake, RMR and NST increased during cold acclimatization. Cytochrome c oxidase (COX) and α-glycerophosphate oxidase (α-GPO) activities in liver and BAT were significantly enhanced during cold acclimatization, and triiodothyronine (T3) and thyroxine (T4) levels in serum were significantly higher than those in the control group. Serum leptin levels decreased after cold acclimatization. Low temperature significantly increased the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), while it decreased cocaine- and amphetamine-regulated transcript peptide (CART) and pro-opiomelanocortin (POMC) expressions. All of the above results suggested that body mass in E. olitor can remain relatively stable at low temperature, which conforms to the ‘set-point hypothesis’. However, the species showed differences with sympatric species, such as E. miletus, Apodemus chevrieri and Tupaia belangeri. Moreover, E. olitor can cope with low temperature by increasing its metabolic rate and thermogenesis properties. The set-point hypothesis states that there is a biological control method in mammals that actively regulates weight toward a predetermined set weight for each individual, which may occur by regulation of energy intake or energy expenditure. In order to investigate the effects of low temperature on body mass regulation in Eothenomys olitor, body mass, body fat mass, food intake, resting metabolic rate (RMR), non-shivering thermogenesis (NST), serum leptin levels, morphology, biochemical indexes of liver and brown adipose tissue (BAT) and hypothalamic neuropeptide genes expression were measured during cold acclimatization. The results showed that there was no significant difference in body mass, but food intake, RMR and NST increased during cold acclimatization. Cytochrome c oxidase (COX) and α-glycerophosphate oxidase (α-GPO) activities in liver and BAT were significantly enhanced during cold acclimatization, and triiodothyronine (T3) and thyroxine (T4) levels in serum were significantly higher than those in the control group. Serum leptin levels decreased after cold acclimatization. Low temperature significantly increased the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), while it decreased cocaine- and amphetamine-regulated transcript peptide (CART) and pro-opiomelanocortin (POMC) expressions. All of the above results suggested that body mass in E. olitor can remain relatively stable at low temperature, which conforms to the ‘set-point hypothesis’. However, the species showed differences with sympatric species, such as E. miletus, Apodemus chevrieri and Tupaia belangeri. Moreover, E. olitor can cope with low temperature by increasing its metabolic rate and thermogenesis properties.Keywords
Funding Information
- National Natural Science Foundation of China (32160254)
- National Natural Science Foundation of China (31760118)
- Young and Middle-aged Academic and Technical Leaders Reserve Talents Program of Yunnan Province (2019HB013)
- Young Talents Program of Yunnan Province (YNWR-QNRC-2019-047)
This publication has 50 references indexed in Scilit:
- Seasonal variation in plasma thyroid hormone concentrations in coastal versus inland populations of juvenile American alligators (Alligator mississippiensis): Influence of plasma iodide concentrationsGeneral and Comparative Endocrinology, 2011
- Set-Point Theory and ObesityMetabolic Syndrome and Related Disorders, 2011
- Advantage to lower body temperatures for a small mammal (Rattus fuscipes) experiencing chronic coldJournal of Mammalogy, 2010
- Limits to sustained energy intake XII: is the poor relation between resting metabolic rate and reproductive performance because resting metabolism is not a repeatable trait?Journal of Experimental Biology, 2010
- Role of hypoleptinemia during cold adaptation in Brandt's voles (Lasiopodomys brandtii)American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- Adaptive thermogenesis in Brandt's vole (Lasiopodomys brandti) during cold and warm acclimationJournal of Thermal Biology, 2009
- Basal metabolic rate and organ size in Brandt's voles (Lasiopodomys brandtii): Effects of photoperiod, temperature and diet qualityPhysiology & Behavior, 2006
- Seasonal thermogenesis and body mass regulation in plateau pikas (Ochotona curzoniae)Oecologia, 2006
- Leptin administration to cold-acclimated rats reduces both food intake and brown adipose tissue thermogenesisJournal of Thermal Biology, 2003
- Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridizationFEBS Letters, 1996