Phosphorylation and Proteolytic Cleavage of Notch in Canonical and Noncanonical Notch Signaling
- 1 January 2020
- book chapter
- research article
- Published by Springer Science and Business Media LLC in Advances in experimental medicine and biology
- Vol. 1227, 51-68
- https://doi.org/10.1007/978-3-030-36422-9_4
Abstract
The Notch signaling pathway seems deceptively simple, with its key feature being a direct connection between extracellular signal and transcriptional output without the need for an extended chain of protein intermediaries as required by so many other signaling paradigms. However, this apparent simplicity hides considerable complexity. Consistent with its central role in many aspects of development, Notch signaling has an extensive collection of mechanisms that it employs alongside of its core transcriptional machinery. These so-called noncanonical Notch pathways diversify the potential outputs of Notch, and allow it to coordinate regulation of many aspects of the biology of cells. Here we will review noncanonical Notch signaling with special attention to the role of posttranslational modifications of Notch. We will also consider the importance of coordinating the activity of gene expression with regulation of cell morphology in biological processes, including axon guidance and other morphological events during embryogenesis.This publication has 106 references indexed in Scilit:
- Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulationCell Death & Disease, 2013
- Notch signaling and neural connectivityCurrent Opinion in Genetics & Development, 2012
- Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and ActinDevelopmental Cell, 2012
- Vangl2 Promotes Wnt/Planar Cell Polarity-like Signaling by Antagonizing Dvl1-Mediated Feedback Inhibition in Growth Cone GuidanceDevelopmental Cell, 2011
- Presenilin-Dependent Receptor Processing Is Required for Axon GuidanceCell, 2011
- The Canonical Notch Signaling Pathway: Unfolding the Activation MechanismCell, 2009
- Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral CortexNeuron, 2008
- Molecular separation of two signaling pathways for the receptor, NotchDevelopmental Biology, 2008
- Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveNature, 2004
- Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell FatesNeuron, 1996