Time interval between (chemo)radiotherapy and subsequent laryngectomy is not prognostic for post operative complications and survival
Open Access
- 1 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Archives of Oto-Rhino-Laryngology
- Vol. 278 (7), 2511-2516
- https://doi.org/10.1007/s00405-020-06384-y
Abstract
Purpose Pharyngocutaneous fistula (PCF) formation and swallowing difficulties are common and troublesome complications following total laryngectomy (TL). Prior (chemo)radiotherapy ((C)RT) is thought to be a risk factor for these complications, but there is conflicting evidence as to whether the time interval between (C)RT and TL is important. The impact of time interval on these complications and also its impact on overall survival are investigated. Methods This is a retrospective case note review of all patients undergoing TL at the University Medical Center, Utrecht, The Netherlands over the 10-year period from January 2008 to December 2017. The cohort was split into those who underwent TL within a year of finishing (C)RT and those longer than 1 year. Results One hundred and twenty-six patients (108 males, 18 females), with a mean age of 66 underwent total laryngectomy after prior (C)RT in the study period. Overall 5-year survival was 35% with a median follow-up of 30 months. Fifty-four patients underwent laryngectomy within a year of their (C)RT versus 72 patients who had a time interval of more than one year. No differences in PCF rate, risk of dilatation or overall survival could be found between the two groups. Conclusions In this modern cohort, time interval between (C)RT and surgery did not impact PCF rate, risk of dilatation or overall survival.Funding Information
- University Medical Center Utrecht
This publication has 23 references indexed in Scilit:
- Time interval between primary radiotherapy and salvage laryngectomy: a predictor of pharyngocutaneous fistula formationEuropean Archives of Oto-Rhino-Laryngology, 2013
- Pharyngocutaneous fistula after salvage laryngectomy: Impact of interval between radiotherapy and surgery, and performance of bilateral neck dissectionHead & Neck, 2013
- Salvage laryngectomy: Oncological and functional outcomeOral Oncology, 2011
- Neck Dissection After ChemoradiotherapyJAMA Otolaryngology–Head & Neck Surgery, 2010
- Complications in Head and Neck SurgeryJAMA Otolaryngology–Head & Neck Surgery, 2006
- Controversies in the management of advanced laryngeal squamous cell carcinomaCancer, 2004
- Salvage laryngectomy and pharyngocutaneous fistulae after primary radiotherapy for head and neck cancer: A national survey from DAHANCAHead & Neck, 2003
- The Role of Cervical Lymphadenectomy After Aggressive Concomitant ChemoradiotherapyJAMA Otolaryngology–Head & Neck Surgery, 2000
- Fistulae following laryngectomy in patients treated with irradiationThe Journal of Laryngology & Otology, 1993
- Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal CancerThe New England Journal of Medicine, 1991