Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan
Open Access
- 22 July 2020
- journal article
- research article
- Published by Wiley in Journal of Clinical Laboratory Analysis
- Vol. 34 (9)
- https://doi.org/10.1002/jcla.23371
Abstract
Background Dengue is a viral disease, transmitted by infected Aedes aegypti and Aedes albopictu s female mosquitoes. Worldwide, 96 million infections were estimated in 2010. The dengue virus comprises four distinct serotypes (DENV‐1, DENV‐2, DENV‐3, and DENV‐4) which belong to the genus Flavivirus. Determining the serotypes during dengue outbreaks is crucial for its effective management in terms of diagnostics improvement and polyvalent vaccine development. The aim of the present study is to determine the prevalence rate of dengue virus serotypes in the samples collected from patients during the 2017 outbreak in Khyber Pakhtunkhwa, Pakistan. Methods A total of 800 ELISA‐positive samples were collected, of which 513 (290 males, 223 females) samples were confirmed positive by PCR. Results Out of 513, 25 were found serotype 1 (5%), 196 were serotype 2 (38%), 192 were serotype 3 (37%), 56 were serotype 4 (11%), and 44 (8%) were found to have mix serotypes. Conclusion We can conclude that serotypes 2 and 3 of dengue virus were the predominated serotypes of dengue virus in the 2017 outbreak in Peshawar, capital city of Khyber Pakhtunkhwa, Pakistan.Keywords
Funding Information
- Higher Education Commission, Pakistan (21‐1818/, SRGP, /R&D/, HEC, /2018)
This publication has 31 references indexed in Scilit:
- Angiotensin AT2 Receptor Contributes towards Gender Bias in Weight GainPLOS ONE, 2013
- Dengue viruses – an overviewInfection Ecology & Epidemiology, 2013
- Control of dengue fever in PakistanNature, 2011
- Serotype and genotype analysis of dengue virus by sequencing followed by phylogenetic analysis using samples from three mini outbreaks-2007-2009 in PakistanBMC Microbiology, 2011
- Dengue — Quo tu et quo vadis?Viruses, 2011
- Multiple dengue serotypes and high frequency of dengue hemorrhagic fever at two tertiary care hospitals in Lahore during the 2008 dengue virus outbreak in Punjab, PakistanInternational Journal of Infectious Diseases, 2010
- Demographic and Clinical Features of Dengue Fever in Pakistan from 2003–2007: A Retrospective Cross-Sectional StudyPLOS ONE, 2010
- Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and MalariaPLoS Medicine, 2006
- Transmission of Dengue Virus without a Mosquito Vector: Nosocomial Mucocutaneous Transmission and Other Routes of TransmissionClinical Infectious Diseases, 2004
- West Nile virus in Pakistan. 1. Sero-epidemiological studies in Punjab ProvinceTransactions of the Royal Society of Tropical Medicine and Hygiene, 1982