Detection of Cardiac Structural Abnormalities in Fetal Ultrasound Videos Using Deep Learning
Open Access
- 2 January 2021
- journal article
- research article
- Published by MDPI AG in Applied Sciences
- Vol. 11 (1), 371
- https://doi.org/10.3390/app11010371
Abstract
Artificial Intelligence (AI) technologies have recently been applied to medical imaging for diagnostic support. With respect to fetal ultrasound screening of congenital heart disease (CHD), it is still challenging to achieve consistently accurate diagnoses owing to its manual operation and the technical differences among examiners. Hence, we proposed an architecture of Supervised Object detection with Normal data Only (SONO), based on a convolutional neural network (CNN), to detect cardiac substructures and structural abnormalities in fetal ultrasound videos. We used a barcode-like timeline to visualize the probability of detection and calculated an abnormality score of each video. Performance evaluations of detecting cardiac structural abnormalities utilized videos of sequential cross-sections around a four-chamber view (Heart) and three-vessel trachea view (Vessels). The mean value of abnormality scores in CHD cases was significantly higher than normal cases (p < 0.001). The areas under the receiver operating characteristic curve in Heart and Vessels produced by SONO were 0.787 and 0.891, respectively, higher than the other conventional algorithms. SONO achieves an automatic detection of each cardiac substructure in fetal ultrasound videos, and shows an applicability to detect cardiac structural abnormalities. The barcode-like timeline is informative for examiners to capture the clinical characteristic of each case, and it is also expected to acquire one of the important features in the field of medical AI: the development of “explainable AI.”Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (the subsidy for Advanced Integrated Intelligence Platform)
This publication has 29 references indexed in Scilit:
- Diagnosis and Treatment of Fetal Cardiac DiseaseCirculation, 2014
- AIUM Practice Guideline for the Performance of Fetal EchocardiographyJournal of Ultrasound in Medicine, 2013
- ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heartUltrasound in Obstetrics & Gynecology, 2013
- Prenatal Detection of Congenital Heart DiseaseThe Journal of Pediatrics, 2009
- ACOG Practice Bulletin No. 101: Ultrasonography in PregnancyObstetrics & Gynecology, 2009
- Prenatal screening for congenital heart disease with four‐chamber and outflow‐tract views: a multicenter studyUltrasound in Obstetrics & Gynecology, 2006
- Prenatal detection of heart defects in a non‐selected population of 30 149 fetuses—detection rates and outcomeUltrasound in Obstetrics & Gynecology, 2006
- Trends in Prenatal Diagnosis of Critical Cardiac Defects in an Integrated Obstetric and Pediatric Cardiac Imaging CenterJournal of Perinatology, 2004
- Temporal variability in birth prevalence of cardiovascular malformationsHeart, 2000
- Outcome of congenital heart defects - a population-based studyActa Paediatrica, 2000