A pilot study in men to show the effects of postural fluid shifts on the severity of obstructive sleep apnea
- 1 December 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Sleep and Breathing
- Vol. 24 (4), 1623-1631
- https://doi.org/10.1007/s11325-020-02044-x
Abstract
Purpose Studies reveal that rostral fluid shifts due to body posture changes from standing to lying down may narrow the upper airway. However, without credible and direct experimental evidence, it remains unclear what the role of natural fluid redistribution in the neck is in affecting obstructive sleep apnea (OSA) severity. Our aim is using direct experimental evidence to determine whether or not postural fluid shifts affect OSA severity. Methods We performed overnight polysomnography on two consecutive nights for 22 men. The bed was set horizontally on the control night, while its tail part was lowered by 30 degrees on the experimental night to reduce the amount of fluid shifted into the neck. We measured sleep and anthropometric parameters on each night. Results The mean (95% CI) apnea-hypopnea index (AHI) in the supine head and trunk position decreased from 66.6 events per hour (57.6-75.6) to 61.2 (52.0-70.4) (t= 4.507,p<0.001), and the oxygen desaturation index from 69.5 events per hour (56.4-82.6) to 61.6 (50.5-72.6) (t= 3.293,p= 0.004), from the control to the experimental night with a decrease in the change of leg fluid volume from 17.7% (15.7-19.8) to 4.7% (1.9-7.5) (t= 11.659,p< 0.001). Conclusions Our findings provide direct experimental evidence to show that natural fluid shift caused by the day-to-night posture change does contribute to OSA pathogenesis and severity. It is likely that the neck fluid increase from an actual day-to-night position change, with 90 degrees change in posture, would produce a much larger AHI increase than the 11.2% found in this study, which contains only a 30 degrees change in posture. These findings suggest that reducing the amount of fluid in the neck region may relieve airway obstructions for patients with moderate and severe OSA.Keywords
Funding Information
- National Natural Science Foundation of China (31670959, 81171422)
- National Science and Technology Pillar Program of China (2012BAI05B03)
- Key Projects in Science and Technology Program of Beijing Municipal Education Commission, China (KZ201210025022)
This publication has 30 references indexed in Scilit:
- Relationship of pharyngeal water content and jugular volume with severity of obstructive sleep apnea in renal failureNephrology Dialysis Transplantation, 2012
- Differing Relationship of Nocturnal Fluid Shifts to Sleep Apnea in Men and Women With Heart FailureCirculation: Heart Failure, 2012
- Rostral overnight fluid shift in end-stage renal disease: relationship with obstructive sleep apneaNephrology Dialysis Transplantation, 2011
- Effects of venous compression of the legs on overnight rostral fluid shift and obstructive sleep apneaRespiratory Physiology & Neurobiology, 2011
- Relationship Between Overnight Rostral Fluid Shift and Obstructive Sleep Apnea in Drug-Resistant HypertensionHypertension, 2010
- Lower body positive pressure increases upper airway collapsibility in healthy subjectsRespiratory Physiology & Neurobiology, 2008
- Alterations in upper airway cross-sectional area in response to lower body positive pressure in healthy subjectsThorax, 2007
- Fluid Shift by Lower Body Positive Pressure Increases Pharyngeal Resistance in Healthy SubjectsAmerican Journal of Respiratory and Critical Care Medicine, 2006
- Passive Leg Raising Does Not Produce a Significant or Sustained Autotransfusion EffectJournal Of Trauma-Injury Infection and Critical Care, 1982
- Radionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man.Circulation, 1981