Update: Innate Lymphoid Cells in Inflammatory Bowel Disease
- 20 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Digestive Diseases and Sciences
- Vol. 67 (1), 56-66
- https://doi.org/10.1007/s10620-021-06831-8
Abstract
Inflammatory bowel disease (IBD) is a chronic and nonspecific intestinal inflammatory condition with high relapse rate. Its pathogenesis has been linked to dysbacteriosis, genetic and environmental factors. In recent years, a new type of lymphocytes, termed innate lymphoid cells, has been described and classified into three subtypes of innate lymphoid cells—group 1, group 2 and group 3. An imbalance among these subsets’ interaction with gut microbiome, and other immune cells affects intestinal mucosal homeostasis. Understanding the role of innate lymphoid cells may provide ideas for developing novel and targeted approaches for treatment of IBD.Keywords
Funding Information
- National Natural Science Foundation of China (no. 81970494 and 81670504)
- Key Research and Development Program of Hunan Province (no. 2019SK2041)
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