Prospective Evaluation of Accuracy of Liver Biopsy Findings in the Identification of Chemotherapy-Associated Liver Injuries

Abstract

Among patients with colorectal liver metastases, preoperative chemotherapy now plays a key role. Preoperative chemotherapy allows selection of good candidates for surgery; reduction of lesion size, enabling more conservative and more radical resections; and treatment of occult disease foci.^1-5 A recent randomized trial conducted by the European Organisation for the Research and Treatment of Cancer demonstrated that neoadjuvant treatments even improve disease-free survival rates.⁶