Discrepancy Between Clinical Diagnosis and Whole-exome Sequencing-based Clonality Analysis of Synchronous Multiple Oral Cancers
- 30 January 2021
- journal article
- research article
- Published by Anticancer Research USA Inc. in Anticancer Research
- Vol. 41 (2), 1035-1040
- https://doi.org/10.21873/anticanres.14859
Abstract
Background/Aim: The definition of multiple oral cancers is based on the distances between the tumors. However, it is not possible to accurately predict tumor origins based only on clinical criteria. Patients and Methods: We performed whole-exome sequencing (WES) to analyze the genetic alterations in five tumors of two patients who underwent surgery in our hospital. Results: In case 1, the distances between tumors on the right mandibular gingiva and buccal mucosa were more than 15 mm, leading to a clinical diagnosis of multiple primary tumors. WES revealed common mutations between tumors, suggesting that the tumors were derived from the same clone. In contrast, in case 2, the distance between tumors on the right side of the tongue was only 10 mm, but the tumors were diagnosed as double primary tumors because their mutations were completely different. Conclusion: WES, rather than the available clinical criteria, can clarify the clonal origins of multiple oral cancers.Keywords
This publication has 15 references indexed in Scilit:
- Clonal analysis as a prognostic factor in multiple oral squamous cell carcinomaOral Oncology, 2017
- Intrinsic HER2 V777L mutation mediates resistance to trastuzumab in a breast cancer patientMedical Oncology, 2016
- Touch imprint cytology with massively parallel sequencing (TIC‐seq): a simple and rapid method to snapshot genetic alterations in tumorsCancer Medicine, 2016
- Targeted and exome sequencing identified somatic mutations in hepatocellular carcinomaHepatology Research, 2016
- Analysis of tumor-derived DNA in plasma and bone marrow fluid in lung cancer patientsMedical Oncology, 2016
- General Rules for Clinical and Pathological Studies on Oral Cancer: A SynopsisJapanese Journal of Clinical Oncology, 2012
- Patient With Multiple Primary Carcinomas Including 4 Separate Oral Cancers: Study of p53 Mutations and Their Implications for ManagementJournal of Oral and Maxillofacial Surgery, 2006
- Second primary tumors and field cancerization in oral and oropharyngeal cancer: Molecular techniques provide new insights and definitionsHead & Neck, 2002
- Comparative p53 mutational analysis of multiple primary cancers of the upper aerodigestive tractSurgery, 1996
- Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and NeckThe New England Journal of Medicine, 1990