Of Mice and Men: Impacts of Calorie Restriction on Metabolomics of the Cerebellum
Open Access
- 9 February 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
- Vol. 76 (4), 547-551
- https://doi.org/10.1093/gerona/glab041
Abstract
The main purpose of research in mice is to explore metabolic changes in animal models and then predict or propose potential translational benefits in humans. Although some researchers in the brain research field have mentioned that the mouse experiments results still lack the complex neuroanatomy of humans, caution is required to interpret the findings. In mice, we observed in article seventeenth of the series of the effects of graded levels of calorie restriction, metabolomic changes in the cerebellum indicated activation of hypothalamocerebellar connections driven by hunger responses. Therefore, the purpose of the current perspective is to set this latest paper into a wider context of the physiological, behavioral, and molecular changes seen in these mice and to compare and contrast them with previous human studies.Keywords
Funding Information
- Biotechnology and Biological Sciences Research Council (BB/G009953/1, BB/P009875/1, BB/J020028/1)
- National Science Foundation of China
- National Institutes of Health (AGO49494)
- Medical Research Postdoctoral Fellowships in Aging Research
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