Visible-Light-Mediated C–I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator
- 8 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 23 (18), 7306-7310
- https://doi.org/10.1021/acs.orglett.1c02905
Abstract
Herein, we report a protocol for direct visible-light-mediated C–I difluoroallylation reactions of α-trifluoromethyl arylalkenes with alkyl iodides at room temperature with an α-aminoalkyl radical as a mediator. The protocol permits efficient functionalization of various α-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.Keywords
Funding Information
- National Natural Science Foundation of China (21732002, 22077071)
- Frontiers Science Center for New Organic Matter, Nankai University (63181206)
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