Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis
Open Access
- 11 February 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via soluble anaphylatoxins. This response is used to control microorganisms and to remove dead cells, but also plays a major role in stimulating the adaptive immune response and the regeneration of injured tissues. Many of these effects inherently depend on complement receptors expressed on leukocytes and parenchymal cells, which, by recognizing complement-derived molecules, promote leukocyte recruitment, phagocytosis of microorganisms and clearance of immune complexes. Here, the plethora of information on the role of complement receptors will be reviewed, including an analysis of how this functionally and structurally diverse group of molecules acts jointly to exert the full extent of complement regulation of homeostasis.Keywords
Funding Information
- Fonds Wetenschappelijk Onderzoek (11A4220N, 1S56521N, G058421N, G080818N)
- H2020 Marie Skłodowska-Curie Actions (MSCA-IF-2018-839632)
- Onderzoeksraad, KU Leuven
This publication has 309 references indexed in Scilit:
- Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsOnline Journal of Public Health Informatics, 2010
- Complement: a key system for immune surveillance and homeostasisNature Immunology, 2010
- Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2Proceedings of the National Academy of Sciences of the United States of America, 2010
- The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal TransductionOnline Journal of Public Health Informatics, 2010
- Dynamics of Neutrophil Migration in Lymph Nodes during InfectionImmunity, 2008
- Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosusProceedings of the National Academy of Sciences of the United States of America, 2007
- Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascadeThe Journal of Experimental Medicine, 2006
- Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophilsThe Journal of Experimental Medicine, 2006
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Mac‐1: a macrophage differentiation antigen identified by monoclonal antibodyEuropean Journal of Immunology, 1979