Non‐coding RNAs in cardiomyocyte proliferation and cardiac regeneration: Dissecting their therapeutic values
Open Access
- 25 January 2021
- journal article
- review article
- Published by Wiley in Journal of Cellular and Molecular Medicine
- Vol. 25 (5), 2315-2332
- https://doi.org/10.1111/jcmm.16300
Abstract
Cardiovascular diseases are associated with high incidence and mortality, contribute to disability and place a heavy economic burden on countries worldwide. Stimulating endogenous cardiomyocyte proliferation and regeneration has been considering as a key to repair the injured heart caused by ischaemia. Emerging evidence has proved that non-coding RNAs participate in cardiac proliferation and regeneration. In this review, we focus on the observation and mechanism that microRNAs (or miRNAs), long non-coding RNAs (or lncRNAs) and circular RNA (or circRNAs) regulate cardiomyocyte proliferation and regeneration to repair a damaged heart. Furthermore, we highlight the potential therapeutic role of some non-coding RNAs used in stimulating CMs proliferation. Finally, perspective on the development of non-coding RNAs therapy in cardiac regeneration is presented.Keywords
Funding Information
- National Natural Science Foundation of China (81670257, 81970227, 82000244)
- China Postdoctoral Science Foundation (2020M671751)
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