From cytosol to mitochondria: the beginning of a protein journey
- 1 May 2020
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 401 (6-7), 645-661
- https://doi.org/10.1515/hsz-2020-0110
Abstract
Mitochondrial protein import is one of the key processes during mitochondrial biogenesis that involves a series of events necessary for recognition and delivery of nucleus-encoded/cytosol-synthesized mitochondrial proteins into the organelle. The past research efforts have mainly unraveled how membrane translocases ensure the correct protein sorting within the different mitochondrial subcompartments. However, early steps of recognition and delivery remain relatively uncharacterized. In this review, we discuss our current understanding about the signals on mitochondrial proteins, as well as in the mRNAs encoding them, which with the help of cytosolic chaperones and membrane-receptors support protein-targeting to the organelle in order to avoid improper localization. In addition, we discuss recent findings that-illustrate how mistargeting of mitochondrial -proteins triggers stress responses, aiming to restore cellular homeostasis.Keywords
This publication has 146 references indexed in Scilit:
- Saccharomyces cerevisiae Porin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45pPublished by Elsevier BV ,2012
- In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at workProceedings of the National Academy of Sciences of the United States of America, 2011
- PUF proteins: repression, activation and mRNA localizationTrends in Cell Biology, 2011
- Tom20 Mediates Localization of mRNAs to Mitochondria in a Translation-Dependent MannerMolecular and Cellular Biology, 2010
- Molecular Chaperone Hsp70/Hsp90 Prepares the Mitochondrial Outer Membrane Translocon Receptor Tom71 for Preprotein LoadingPublished by Elsevier BV ,2009
- Alternative function for the mitochondrial SAM complex in biogenesis of α-helical TOM proteinsThe Journal of cell biology, 2007
- Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by nonhomologous random recombination and in vivo selectionNucleic Acids Research, 2007
- Multiple 40-kDa Heat-Shock Protein Chaperones Function in Tom70-dependent Mitochondrial ImportMolecular Biology of the Cell, 2007
- Mitochondria-associated Yeast mRNAs and the Biogenesis of Molecular ComplexesMolecular Biology of the Cell, 2007
- Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeastThe Journal of cell biology, 2007