Access to P-stereogenic compounds via desymmetrizing enantioselective bromination
Open Access
- 12 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 12 (12), 4582-4587
- https://doi.org/10.1039/d0sc07008d
Abstract
A novel and efficient desymmetrizing asymmetric ortho-selective mono-bromination of bisphenol phosphine oxides under chiral squaramide catalysis was reported. Using this asymmetric ortho-bromination strategy, a wide range of chiral bisphenol phosphine oxides and bisphenol phosphinates were obtained with good to excellent yields (up to 92%) and enantioselectivities (up to 98.5 : 1.5 e.r.). The reaction could be scaled up, and the synthetic utility of the desired P-stereogenic compounds was proved by transformations and application in an asymmetric reaction.Funding Information
- National Natural Science Foundation of China (21971120, 21933008)
- Natural Science Foundation of Tianjin City (18JCYBJC28400)
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