The novel occurrence of Helenium amarum (Raf.) H. Rock var. amarum and Pulicaria dysenterica (L.) Gaertn. (Asteraceae) in the flora of Egypt is reported. Apart from the single collection of H. amarum var. amarum in Australia, this taxon was not recorded previously outside its country of origin in South-Eastern United States and Mexico. With the recording of Pulicaria dysenterica in Egypt, Libya remains the only Mediterranean country where it has not as yet been found. Detailed description of the two species in terms of 83 characters is provided. A data matrix including the eight Pulicaria species found in Egypt and 19 of their morphological characters was compiled and a conventional key was constructed using the key-generating computer program suit DELTA.