The study is to describe a patient with urticarial lesions which was successfully treated with mindfulness and nutraceuticals. A 20-year-old female patient with an unmarked past medical history presented with diffuse pruritic urticarial lesions associated with breathless and severe fatigue, lasting for 5 months. The lesions covered all body, except palms and plants. Hospitalized for three days, she received dexamethasone, promethazine, and subcutaneous adrenalin and discharged with fexofenadine, prednisone, and ranitidine. Mindfulness and relaxation practice were instructed and some nutraceuticals. After two months, she returned asymptomatic, without any new episodes of urticaria or fatigue. Most of the chronic urticaria patients are treated with antihistamines and/or steroids. This case illustrates an alternative holistic approach, combining mindfulness and relaxation practices with nutraceuticals. This alternative therapeutical strategy should be explored by back to back comparison to the conventional pharmaceutical approach.