Comparative study of bone regeneration using fibrin sealant with xenograft in rabbit sinus: pilot study
Open Access
- 10 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Maxillofacial Plastic and Reconstructive Surgery
- Vol. 43 (1), 1-6
- https://doi.org/10.1186/s40902-021-00290-x
Abstract
Background: Stability of the grafted bone volume is one of the important factors to the success of alveolar bone grafts. For this, platelet-rich plasma (PRP) or fibrin sealant is mixed with the bone graft material. Bio-Oss® is a protein-free bovine mineral commonly used in bone graft procedures. The grafting particles are commonly combined with a standard fibrin sealant (Tisseel®) to fabricate a plastic implantable product. The purpose of this experiment was to evaluate the efficacy of fibrin sealant (Tisseel®) in bone regeneration performance in a rabbit maxillary sinus model. Methods: A total of five 3.5 kg weight New Zealand white rabbits were used for the study. After elevating the sinus membrane in both maxillary sinus cavities, Bio-Oss® mixed with normal saline (group 1) was filled into the right side, and Tisseel® mixed Bio-Oss® (group 2) was inserted into the other side. The bone mineral density and bone volume were analyzed with microscopic computed tomography (micro-CT) and histomorphometric 12 weeks after application. Results: Histologically, new bone formation rate was 14.8%, and grafted bone rate was 70.5% in group 1. In group 2, they were 18.5% and 60.4%, respectively. According to micro-CT analysis, bone mineral density (mg/cm3, BMD) was 2.5% larger in group 1. Conclusions: The findings from this study suggest that, although the difference in the bone formation between group 1 and group 2 appears to be insignificant, group 2 had an advantage in using smaller amount of bone substances to achieve the reliable bone formation.Keywords
Funding Information
- Pusan National University (2-year Research Grant)
This publication has 28 references indexed in Scilit:
- Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric studyJournal of Cranio-Maxillofacial Surgery, 2012
- Comparison of two bone substitute biomaterials consisting of a mixture of fibrin sealant (Tisseel®) and MBCP™(TricOs®) with an autograft in sinus lift surgery in sheepClinical Oral Implants Research, 2009
- A 3-year prospective follow-up study of implant-supported fixed prostheses in patients subjected to maxillary sinus floor augmentation with a 80:20 mixture of deproteinized bovine bone and autogenous bone: Clinical, radiographic and resonance frequency analysisInternational Journal of Oral & Maxillofacial Surgery, 2005
- Bone Formation in the Maxillary Sinus by Using Platelet-rich Plasma: An Experimental Study in SheepJournal of Oral Implantology, 2005
- The effect of a fibrin glue on the integration of Bio‐Oss® with bone tissueJournal of Clinical Periodontology, 2002
- Bovine hydroxyapatite for maxillary sinus grafting: comparative histomorphometric findings in sheepClinical Oral Implants Research, 1998
- Complication rate with prosthodontic reconstructions on ITI and IMZ dental implantsClinical Oral Implants Research, 1998
- Sinus elevation procedures in the resorbed posterior maxilla: Comparison of the crestal and lateral approachesOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 1998
- Bone apposition onto oral implants in the sinus area filled with different grafting materials. A histological study in beagle dogs.Clinical Oral Implants Research, 1995
- Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogsActa Orthopaedica, 1986