Determination of topographical radiation dose profiles using gel nanosensors
Open Access
- 1 November 2019
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 5 (11), eaaw8704
- https://doi.org/10.1126/sciadv.aaw8704
Abstract
Despite the emergence of sophisticated technologies in treatment planning and administration, routine determination of delivered radiation doses remains a challenge due to limitations associated with conventional dosimeters. Here, we describe a gel-based nanosensor for the colorimetric detection and quantification of topographical radiation dose profiles in radiotherapy. Exposure to ionizing radiation results in the conversion of gold ions in the gel to gold nanoparticles, which render a visual change in color in the gel due to their plasmonic properties. The intensity of color formed in the gel was used as a quantitative reporter of ionizing radiation. The gel nanosensor was used to detect complex topographical dose patterns including those administered to an anthropomorphic phantom and live canine patients undergoing clinical radiotherapy. The ease of fabrication, operation, rapid readout, colorimetric detection, and relatively low cost illustrate the translational potential of this technology for topographical dose mapping in radiotherapy applications in the clinic.Keywords
Funding Information
- National Science Foundation (NSF-CBET 1403860)
This publication has 43 references indexed in Scilit:
- Formation of Gold Nanorods by a Stochastic “Popcorn” MechanismACS Nano, 2012
- Inorganic nanoparticles for cancer imaging and therapyJournal of Controlled Release, 2011
- A Radio‐Fluorogenic Organic Gel for Real‐Time, 3D Radiation DosimetryAdvanced Materials, 2011
- Doses to internal organs for various breast radiation techniques - implications on the risk of secondary cancers and cardiomyopathyRadiation Oncology, 2011
- Electrophoresis of DNA in agarose gels, polyacrylamide gels and in free solutionElectrophoresis, 2009
- Scintillating Metal‐Organic Frameworks: A New Class of Radiation Detection MaterialsAdvanced Materials, 2009
- Canine Anatomic Phantom for Preclinical Dosimetry in Internal Emitter TherapyJournal of Nuclear Medicine, 2008
- Electric‐Field‐Directed Growth of Gold Nanorods in Aqueous Surfactant SolutionsAdvanced Functional Materials, 2004
- Synthesis and Characterization of Gold Sulfide NanoparticlesLangmuir, 2001
- Pore size of agarose gels by atomic force microscopyElectrophoresis, 1997