Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma
Open Access
- 12 June 2020
- Vol. 12 (6), 1568
- https://doi.org/10.3390/cancers12061568
Abstract
Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations in EHD1, ATM, FBXO10, SH2D2A, CDH5, MAGED1, and TP73 shared by WDPM cases but not reported in malignant mesotheliomas. Furthermore, we show that WDPM is strongly enriched with C > A transversion substitution mutations, a pattern that is also not found in malignant mesotheliomas. The WDPMs lacked the alterations involving BAP1, SETD2, NF2, CDKN2A/B, LASTS1/2, PBRM1, and SMARCC1 that are frequently found in malignant mesotheliomas. We conclude that WDPMs are neoplasms that are genetically distinct from malignant mesotheliomas and, based on observed mutations, do not appear to be precursors of malignant mesotheliomas.Keywords
This publication has 34 references indexed in Scilit:
- BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesotheliomaGenome Medicine, 2019
- Integrative Molecular Characterization of Malignant Pleural MesotheliomaCancer Discovery, 2018
- Well differentiated papillary peritoneal mesothelioma treated by cytoreduction and hyperthermic intraperitoneal chemotherapy-the experience of the PSOGI registryEuropean Journal of Surgical Oncology, 2018
- BAP1 loss is unusual in well-differentiated papillary mesothelioma and may predict development of malignant mesotheliomaHuman Pathology, 2018
- Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterationsNature Genetics, 2016
- Well-differentiated papillary mesothelioma: clustering in a Portuguese family with a germline BAP1 mutationAnnals Of Oncology, 2013
- Heterozygous loss of NF2 is an early molecular alteration in well-differentiated papillary mesothelioma of the peritoneumCancer Genetics, 2012
- First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneumGenome Biology, 2011
- Well-Differentiated Papillary MesotheliomaThe American Journal of Surgical Pathology, 2001
- Well-differentiated papillary mesothelioma of the peritoneum. A clinicopathologic study of 22 casesCancer, 1990