Radio-Enhancing Properties of Bimetallic Au:Pt Nanoparticles: Experimental and Theoretical Evidence
Open Access
- 12 November 2019
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 20 (22), 5648
- https://doi.org/10.3390/ijms20225648
Abstract
The use of nanoparticles, in combination with ionizing radiation, is considered a promising method to improve the performance of radiation therapies. In this work, we engineered mono- and bimetallic core-shell gold–platinum nanoparticles (NPs) grafted with poly (ethylene glycol) (PEG). Their radio-enhancing properties were investigated using plasmids as bio-nanomolecular probes and gamma radiation. We found that the presence of bimetallic Au:Pt-PEG NPs increased by 90% the induction of double-strand breaks, the signature of nanosize biodamage, and the most difficult cell lesion to repair. The radio-enhancement of Au:Pt-PEG NPs were found three times higher than that of Au-PEG NPs. This effect was scavenged by 80% in the presence of dimethyl sulfoxide, demonstrating the major role of hydroxyl radicals in the damage induction. Geant4-DNA Monte Carlo simulations were used to elucidate the physical processes involved in the radio-enhancement. We predicted enhancement factors of 40% and 45% for the induction of nanosize damage, respectively, for mono- and bimetallic nanoparticles, which is attributed to secondary electron impact processes. This work contributed to a better understanding of the interplay between energy deposition and the induction of nanosize biomolecular damage, being Monte Carlo simulations a simple method to guide the synthesis of new radio-enhancing agents.This publication has 67 references indexed in Scilit:
- Multifunctional Gold Nanoparticles for Diagnosis and Therapy of DiseaseMolecular Pharmaceutics, 2013
- Au–Pt graded nano-alloy formation and its manifestation in small organics oxidation reactionJournal of Materials Chemistry A, 2013
- Influence of Dose on Particle Size and Optical Properties of Colloidal Platinum NanoparticlesInternational Journal of Molecular Sciences, 2012
- A Straightforward Method For Interpreting XPS Data From Core–Shell NanoparticlesThe Journal of Physical Chemistry C, 2012
- Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in VivoACS Nano, 2012
- Gold nanoparticles as novel agents for cancer therapyThe British Journal of Radiology, 2012
- Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticlesScientific Reports, 2011
- Gold nanoparticles: a new X-ray contrast agentThe British Journal of Radiology, 2006
- Understanding the initial stages of polymer grafting on metals: a photoelectron spectroscopy study of acrylonitrile adsorption on transition metal surfacesJournal of Electron Spectroscopy and Related Phenomena, 2001
- Irradiation of Plasmid and Phage DNA in Water—alcohol Mixtures: Strand Breaks and Lethal Damage as a Function of Scavenger ConcentrationInternational Journal of Radiation Biology, 1993